NFL 2025 Week 16 Predictions: Top 5 Games of the Year Edition

I just remembered a few hours ago that we have two Saturday NFL games for Week 16. One (PHI-WAS) makes me think I don’t mind cleaning the cat’s shit boxes per Saturday routine and missing some plays, and the other (GB-CHI) might be great.

But it’ll take a lot to top what we watched Thursday night when the NFC Game of the Year lived up to the hype and then some. Rams-Seahawks was so good, so shocking, and so impactful that I can’t help but name it the Game of the Year for the 2025 NFL regular season.

Then I saw some people note we’ve had a bunch of GOTY candidates, and I had to come up with a list to see if there’s any truth to that. So, here is my top 5 games of the year for 2025:

  1. Week 16 – Seahawks 38, Rams 37
  2. Week 1 – Bills 41, Ravens 40
  3. Week 3 – Eagles 33, Rams 26
  4. Week 12 – Chiefs 23, Colts 20
  5. Week 4 – Cowboys 40, Packers 40

Probably not good for the Rams that two of the top three games involve them blowing leads of 19 and 16 points in the second half to the defending champs and the leader in their division right now. But the Rams have played entertaining games, and even the first Rams-Seahawks game was close to the top for watching how close Seattle was despite four Darnold interceptions.

We still have some big games left this year, though it’s a huge disappointment that both Commanders-Eagles games are trash and of little relevance. Those were supposed to be huge, but there were just too many injuries for Jayden Daniels and company this season.

This Week’s Articles

The last game of the year for Patrick Mahomes, and my NFL Week 16 picks explain why I’ve been saying for weeks that Drake Maye will have his first 300-yard passing game in Baltimore.

NFL Week 16 Predictions

I’m not sure if I’ve ever had a prediction where I took a team to cover at +1.5 and the opponent to win, but I did it for Rams-Seahawks and I can’t believe Seahawks by 1 worked out in the end. It’s the first game in NFL history where both teams scored a touchdown in overtime and the second team walked it off with a successful 2PC.

But could you imagine the outrage if the total fluke 2PC that tied the game at 30 in the 4Q was the game-winning 2PC in OT? What a disaster that would be, and I would imagine some rules committee discussions this offseason over that one (already saw Sean McVay said there will be).

WAS-PHI: Division games are tricky but I think Eagles get the win and I like DeVonta Smith for props (O56.5, TD).

GB-CHI: It was close at the end last time, and I think with the Micah Parsons injury and homefield switching to the turnover-crazed Bears, they get this one for the big NFC North lead.

LAC-DAL: Cowboys could be eliminated Saturday. But it’s a bigger game either way for the Chargers, and I’m trusting them with the better coach and defense despite the spread.

MIN-NYG: Feels like a game where Dart could get injured, and I think McCarthy will have a good stat line on that defense.

BUF-CLE: Myles Garrett gets his record-tying sack, Bills cover the spread anyway.

NYJ-NO: Tyler Shough is playing well and the Saints cover the laughably large spread after giving up 6 TD to Trevor Lawrence.

TB-CAR: I like the over 45.5 more than trusting either team on the spread, but I think Todd Bowles sees himself getting fired if they blow this division, so give me TB.

CIN-MIA: Hedging on Miami cover, but how funny would it be if the offense lit it up after Tua was benched? Ewers just needs to rely on that running game against the Bengals.

KC-TEN: With the Chiefs facing the 2 worst teams in the NFL this year in their last 3 games (Titans and Raiders), I’m sure fans will be very rational about how they play with Patrick Mahomes on IR. Very rational.

JAX-DEN: Could be a good one and a playoff preview, but I think the Broncos pull it out on a late FG.

ATL-ARI: Maybe a shootout? I’ll trust Captain Kirk in crunch time with his pass rush against Jacoby.

PIT-DET: Expecting solid scoring here, but I think the Lions win a 31-24 game here as they clearly need it more than the Steelers. Expect big things from Amon-Ra St. Brown. 20+ yards in the 1Q for starters. Maybe 2+ catches on the first drive. Exactly the kind of WR who can put up numbers on this defense.

LV-HOU: I tried the Raiders last week and they got crushed 31-0. Screw it, give me Houston and that defense.

NE-BAL: I already said I’m all in on Drake Maye having his first 300-yard passing game, but how about his first 4QC win too? He’s 0-7 in his career. Baltimore is the perfect opponent to do both against, the weather sounds like it’ll be fine, and I can see the Patriots pulling this one out 27-24 late to fill in some gaps in Maye’s resume. Just don’t tell me he’s MVP over Stafford.

SF-IND: I was originally liking the Colts ATS, but -5.5 isn’t as enticing as -6.5. Hard to say though. Philip Rivers should be better in game 2, but I think the 49ers win it after finding out they control their destiny for the No. 1 seed with Sam Darnold in Week 18 only standing in their way really. Could be a repeat of last year when the Lions beat Darnold’s Vikings in prime time to end the regular season and decide the No. 1 seed.

NFL Week 6 Predictions: Game of the Year Edition

Week 6 brings the start of byes and the two biggest games on the schedule to this point. Bills at Chiefs should be the biggest game of the regular season period with everything on the line in that epic matchup. But Cowboys at Eagles is a surprisingly big one in the NFC on Sunday night. It’s just a shame this won’t be Dak Prescott’s return game as that would add more intrigue to it. I expect the Eagles to move to 6-0, and if they get past this one, they may not lose until after Thanksgiving.

Articles this week:

But clearly I’m all about talking Bills-Chiefs this week.

Game of the Year: Bills at Chiefs (+2.5)

I want to draw attention to the nearly 3,000-word QB-centered preview I did for this game already, the first of two previews I wrote about it (see above link too). I covered the first four meetings between Josh Allen and Patrick Mahomes as well as what can happen this time around.

That piece covers a lot of my feelings about this game and budding rivalry, which should be drawing comparisons to the 1990s 49ers-Cowboys and 2000s Colts-Patriots. But for it to step up to that level, the Bills have to be the better team this year. That means winning this game to give themselves the best shot at hosting a rematch in January instead of going to Arrowhead for the third year in a row.

Not only is homefield advantage at stake here, but the leader in the MVP race is going to get a big boost from this outcome, assuming both QBs won’t be as stellar as they were in January’s playoff decision. Someone should create a gap in this game, and my pick for that is Allen going up against the lesser defense. That should be the main reason why the Bills are favored by 2.5 points, the first time Mahomes is a home underdog in the NFL.

But if Mahomes pulls this game out, I think you have to never bet against this guy as an underdog again. He has 28 touchdown passes in eight games as an underdog (6-2 SU, 7-0-1 ATS). I just think this is the game where not having Tyreek Hill is going to stand out, and if the Bills can keep up the attacking style the Raiders had in the first half on both sides of the ball on Monday night when they led 17-0 and 20-10, then they should win this game. I knew before Monday night that I was picking Buffalo in this one, but that emotional Kansas City comeback, fueled largely by a terrible roughing the passer penalty, actually strengthens my pick of Buffalo in this game. I just don’t think the Chiefs have as much margin for error anymore on offense, and the defense is not up to championship caliber like what the Bills have.

Not Sure Allen-Mahomes Can Be Manning-Brady

Something I wanted to touch on that I didn’t write about in either preview was the comparison of Allen and Mahomes to Peyton Manning vs. Tom Brady. These quarterbacks are playing better than anyone else right now, and after meeting in the playoffs the last two years and being the two favorites to win it all (plus MVP) as we head into Week 6, that is why this is possibly the No. 1 rivalry in the NFL today.

But I have a lot of issues with calling Allen-Mahomes the new Manning-Brady.

The first huge problem: which one is which?

Throughout NFL history, so many of the great quarterback rivalries were instances of a naturally gifted player who had to carry his team each year and another top-tier player who had more winning and championship success despite lesser statistics because he was on a better team with superior coaching/defense/ST and maybe just some better luck.

  • Sammy Baugh vs. Sid Luckman
  • Bobby Layne vs. Otto Graham
  • Johnny Unitas vs. Bart Starr
  • Ken Stabler/Roger Staubach vs. Terry Bradshaw
  • Dan Marino/John Elway vs. Joe Montana
  • Steve Young vs. Troy Aikman
  • Peyton Manning vs. Tom Brady

In just about every case there, it is clear which QB is serving which role. But when it comes to Mahomes and Allen, that is not very clear at all.

One of the main hallmarks of a traditional QB rivalry is here with Mahomes having the better stats/weapons/honors and Allen having the better defense, but Mahomes also has the better coach, and he has the better record (reg. season and playoffs) and the only MVP and ring between the two of them.

That really throws this one for a loop, because Mahomes does not match up well with the traditional “rings” QB as he is so prolific as a passer. But in time, this could shake out to make more sense. Maybe Allen wins a couple of Super Bowls here, leapfrogging Mahomes in the ring count and matching him in MVPs. The slow start to Allen’s career (rare Year 3 breakout) certainly does him no favor in these comparisons.

Also, it’s only 2022. There is plenty of time for this to change. This would be like me writing in 2006-07 about comparing Manning and Brady to Marino and Montana. I absolutely could have done it then, and those comparisons are stronger than the ones presented here. But I also can say with confidence what kind of quarterbacks Manning and Brady ultimately turned out to be. We still have no idea if Allen will ever get to a Super Bowl or if Mahomes will win multiple rings/MVPs or not. They both should do great things, but they also are both starring at the same time, and that is going to lead to one limiting the other. Without those 13 seconds last year, Allen might already have a ring.

That’s why hyping this up as a chief NFL rivalry is fun, and why this game deserves hype similar to the levels of 2007 Patriots-Colts (or at least 2017 Patriots-Steelers). Games like this don’t come around often in the regular season. Let’s hope it’s a classic, but if I had to guess which Bills-Chiefs game from 2021 it will look more like, I’d say the 38-20 Buffalo win rather than the 42-36 playoff masterpiece.

Maybe I’ll be wrong about Buffalo, my preseason pick to win it all, but if I’m right about this being their 1994 49ers or 2006 Colts type of year for them to vanquish KC, then that means they are going to win this game.

Final: Bills 31, Chiefs 27

NFL Week 6 Predictions

I nailed my TNF pick (Washington) and I would have nailed my SGP but Carson Wentz is a bum who couldn’t throw for 100 yards.

Like half of Pittsburgh’s defense is out with injury tomorrow, so nice of Tom Brady to catch a break in Year 23. He really deserves one…

The Jaguars may sweep Indy, who is down both RBs again, but that loss to Houston last week really soured me on Trevor Lawrence and the offense. I think Matt Ryan is a threat to fumble every time he’s touched now, which is often behind this OL, but I’m still going to back the Colts this week.

I like the Dolphins to upset the Vikings, who can’t keep pulling off 4QCs every week behind Kirk Cousins. The world isn’t that warped yet. I also think the Ravens are in dangerous territory in NY against the blitzing Giants. It could look like that Miami loss last year where they just teed off on Jackson, so I hedged with NYG ATS/BAL ML.

I’ll change my ATS pick to Carolina if Cooper Kupp doesn’t play, but whatever. Carolina still stinks after going with a different HC (Steve Wilks) and QB (P.J Walker) this week.

Cooper Rush is a wild story and that Dallas defense is tough this year. I just think the Eagles are going to score too much in the first half to get the Cowboys out of their comfort zone. We’ll see.

And finally, I am crazy enough to trust Russell Wilson to play his best game in a Broncos uniform. I wasn’t crazy enough to pick them to win outright, but in a MNF game between Wilson and the Chargers, how the fvck can it not be super close at the end?