It really feels like the NFL stacked this Week 2 schedule at the front (LAC/KC) and back (BUF/TEN, MIN/PHI) and forgot about Sunday.
Also, I have no idea why there is a doubleheader on Monday night in Week 2, and it’s not even a true doubleheader since the games will be going on simultaneously. But I wrote about how Justin Jefferson could follow Cooper Kupp’s lead last year to an Offensive Player of the Year award and maybe more if Kirk Cousins can pull off a Matthew Stafford.
But I really do think the Sunday schedule is lacking tomorrow. Part of that isn’t really the NFL’s fault as Bengals-Cowboys could have been a fun game based on last year, but we didn’t know the Cowboys would be this injured already, especially Dak Prescott again. But check the picks below as I think Cooper Rush can surprise some people.
The weird thing about this week is that five games already have a team favored by 9.5 points, or another way of saying favored to win by double digits.
That is a lot for Week 2, because the spreads usually grow later in the season once we see these teams separate from one another. For example, there were five Week 2 games in 2019-21 combined (three seasons) where a team was favored by double digits. We’re possibly matching that this week depending on where the lines close.
This hasn’t happened in a while. The 2007 and 2006 seasons both had five Week 2 games with a 9.5+ point spread. It usually happens once or twice a season since. If this holds, then 2022 will tie 2006 and 2007 for the most Week 2 games on record of having a spread this big.
In Week 1, we observed a lot of unusually high underdogs at home (5.5+ points) for an opener.
So, what is going on with this season from a betting perspective? Is it a case of the haves vs. have nots?
Maybe some of it is the preseason predictions still carrying too much weight, and teams like Denver and San Francisco may not be as good as we thought they’d be with new quarterbacks. At the same time, maybe teams expected to be among the very worst like Seattle and Atlanta may actually be halfway decent.
We know Week 2 can always be the toughest week of the season to predict because you’re trying to wrap your head around what was real and what was an outlier in the first game. But something I’m looking at for this week’s slate is division familiarity and motivation, and how those factors can change sharply from last week. Here are some examples:
Are the Rams really going to be that bad this year, or were they just playing the Super Bowl favorites from Buffalo who haven’t punted in four of their last six games now? Something tells me the Falcons won’t look that good this week as they did last week when they blew a 16-point lead to division rival New Orleans. Guess what happened last year? A bad Atlanta team blew an 18-point 4Q lead (in less time even than last week) to the Saints, but Matt Ryan got the ball back with enough time to get a FG and avoid the blown lead. I’m not worried about the Rams yet.
Speaking of Ryan, after that slow start in Houston, another division team that usually plays Indy close outside of 2021, I think he has a chance to do big things this week. Sure, the Colts have shit the bed in Jacksonville every year since 2015, but I think he’ll be okay in this game. Still, it’s not one I’d be betting good money on for ML or spread.
Meanwhile, is Houston going to look that decent in Denver? Are the Broncos really this badly coached, or was it just a tough debut in a loud place to play with everyone fired up to beat Russell Wilson? At the same time, will the Seahawks play that well in San Francisco? Oh, that is one I can believe. The 49ers haven’t beat Seattle by 10+ points since the 2011 opener. Kyle Shanahan without Jimmy Garoppolo should not be trusted. The evidence keeps growing by the week. That’s another game I’d avoid ML bets.
NFL Week 2 Predictions
Justin Herbert seriously went from a painful looking injury that prevented him from running for an easy first down on a third down to throwing the pass of the night on fourth-and-1. It led to a touchdown and late cover for the Chargers, who I picked to lose 28-21 on the night. At least the under hit.

I picked the Jets for an upset at first, but I think I’ll just stick with the cover. It seems like every year the Jets are a team I keep betting ATS early, thinking they can’t be this bad, but time and time again, they prove me wrong. They are this bad. But we’ll see against Cleveland.
I think Tom Brady gets his first regular-season win over the Saints with Tampa, but I’d be lying if I said I felt confident about it. Saints look as unpredictable as last year.
This might be the Steelers-Patriots game with the least impact on the AFC since they met in 1991 during bad seasons. Not used to this not being a big game, but I expect low scoring and close. Just can’t imagine Trubisky avoids the big turnovers again this week. The Patriots haven’t been getting takeaways, but all those recent games with 0s in that column were against the Bills and Dolphins. The AFC East has absolutely caught up to them (Jets aside). They won’t be able to beat the Steelers the way they used to, but Mac Jones can dink and dunk to a high completion percentage at least. No T.J. Watt was the deciding factor for me. This is the kind of game he could win on his own with splash plays.
Dolphins-Ravens is potentially the best game on Sunday. We’ll see if the Ravens can protect Lamar Jackson this time. Miami roughed him up good on Thursday night last year. I like Tyreek Hill to score his first touchdown of the season.
I am giving the Cowboys a shot at covering against the Bengals. Maybe Cooper Rush can put on his best Mike White impression. The difference is Rush has a start and 300-yard game and win under his belt over Minnesota last year. Cowboys were beyond bad on offense last week, but maybe Micah Parsons can harass Joe Burrow into more turnovers and sacks. The defense has to get the job done for Dallas now.
On Monday, I think the Bills get some revenge on Tennessee for losses the last two years, but I’m not ready to count out the Titans from keeping it close.
Vikings-Eagles really might be the game of the week as Chargers-Chiefs didn’t quite deliver on expectations. If both of these teams are going to win 10+ games and win division titles, it will be interesting to see how they perform Monday as those are the opponents that both have been losing to for years. The Eagles are 1-15 against playoff teams since drafting Jalen Hurts. The Vikings usually never beat a good team not named the Packers. Looking forward to this one and I think I may end up watching more of it than the Buffalo game.
Why I have to choose at all between two games on a Monday in Week 2? Damned if I knew…